Ontology highlight
ABSTRACT:
SUBMITTER: Milunovic MNM
PROVIDER: S-EPMC7565988 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Biomolecules 20200820 9
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H<sub>2</sub>L<sup>R</sup>]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HL<sup>R</sup>)Cl]Cl (<b>1</b>-<b>4</b>) were synthesised with the aim to study (i) their antiproliferative activity in cancer cells and, (ii) for the first time for thiosemicarbazones, the interaction with membrane transport proteins, specifically organic cation transporters OCT1-3. The compound ...[more]