Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function.

ABSTRACT: BACKGROUND:The impact of weight on pharmacokinetics of gentamicin was recently elucidated for (morbidly) obese individuals with normal renal function. OBJECTIVES:To characterize the pharmacokinetics of gentamicin in real-world obese patients, ultimately to develop dose recommendations applicable across the entire obese population. METHODS:In two large Dutch hospitals, all admitted patients with BMI ?25?kg/m2 with at least one gentamicin administration, at least one gentamicin and at least one creatinine serum concentration measurement were included. Data from one hospital, obtained from electronic health records, combined with prospective data of non-obese and morbidly obese people with normal renal function, served as the training dataset, and data from the second hospital served as the external validation dataset. RESULTS:In the training dataset [1187 observations from 542 individuals, total body weight (TBW) 52-221?kg and renal function (CKD-EPI) 5.1-141.7?mL/min/1.73?m2], TBW was identified as a covariate on distribution volume, and de-indexed CKD-EPI and ICU stay on clearance (all P?

SUBMITTER: Smit C 

PROVIDER: S-EPMC7566361 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature