Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages.
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ABSTRACT:
SUBMITTER: Xiang W
PROVIDER: S-EPMC7566605 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages.
Xiang Wei W Shi Rongchen R Zhang Dapeng D Kang Xia X Zhang Lili L Yuan Jing J Zhang Xuan X Miao Hongming H
Signal transduction and targeted therapy 20201015 1
Peritoneal carcinomatosis (PC) of colorectal cancer (CRC) is a terminal phase of malignancy with no effective strategies for the prevention of this condition. Here we established PC models in mice by intraperitoneal engraftment of CRC cells and revealed an unexpected role for a high-fat diet (HFD) in preventing metastatic seeding in the visceral fat. Mechanistically, the HFD stimulated the activation of adipose tissue macrophages (ATMs) toward an M1-like phenotype and enhanced ATM tumor phagocyt ...[more]
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