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Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

ABSTRACT: Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-?, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton's tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.

SUBMITTER: Gudjonsson JE

PROVIDER: S-EPMC7566715 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Gudjonsson Johann E JE Tsoi Lam C LC Ma Feiyang F Billi Allison C AC van Straalen K R KR Vossen A R J V ARJV van der Zee H H HH Harms Paul W PW Wasikowski Rachael R Yee Christine M CM Rizvi Syed M SM Xing Xianying X Xing Enze E Plazyo Olesya O Zeng Chang C Patrick Matthew T MT Lowe Margaret M MM Burney Richard E RE Kozlow Jeffrey H JH Cherry-Bukowiec Jill R JR Jiang Yanyun Y Kirma Joseph J Weidinger Stephan S Cushing Kelly C KC Rosenblum Michael D MD Berthier Celine C MacLeod Amanda S AS Voorhees John J JJ Wen Fei F Kahlenberg J Michelle JM Maverakis Emanual E Modlin Robert L RL Prens Errol P EP

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Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immu ...[more]

PMID: 32853177

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Project description:Hidradenitis suppurativa (HS) leads to disfigurement and painful eruptions in terminal hair follicles of the intertriginous skin, mainly of axillary, genitofemoral, and perianal sites. It is associated with an excessive impairment of quality of life, psychiatric disorders, and sexual distress. Body image impairment has been linked to depression and anxiety and has been described for some dermatologic disorders but has not yet been investigated in patients with HS.To investigate whether body image is diminished in patients with HS and whether disease severity, age at onset, disease duration, obesity, depression, and anxiety are linked to body image impairment.This 12-month (August 1, 2009, to August 31, 2010) case-control study with a prospective, observational, cross-sectional design recruited 47 consecutive patients with HS entering a tertiary care center and 45 healthy control individuals matched for age, sex, and body mass index (BMI). One patient and 4 controls failed to complete the questionnaire and were excluded from the evaluation. Data analysis was performed from December 1, 2013, to February 15, 2014.The Frankfurt Body Concept Scale (FKKS) and the Hospital Anxiety and Depression Scale (HADS) were given to patients and controls. Correlations among FKKS, HADS, and disease features were calculated.Of the 46 patients and 41 controls included in the evaluation (mean [SD] age, 35.6 [1.6] years; 40 [46%] male and 47 [54%] female), HS significantly reduced body image (mean FKKS score, 234.2 [5.4] in patients and 276.9 [5.7] in controls; P < .001), even when controlled for BMI. A correlation was found for the extent of body image disruption and BMI (r = -0.589; P < .001), HADS-depression score (r = -0.619; P < .001), and HADS-anxiety score (r = -0.340; P = .03). No association was found for the body image score and the severity of HS, age at onset of disease, and duration of disease. The body contact subscale score was the only subscale score that was not different between patients with HS and controls.Patients with HS have major body image impairment, which might lead to depression and anxiety, disorders that have been largely acknowledged in HS. This study identified another element of the psychosocial burden of patients with HS and reveals that body image could potentially be used as an outcome measure in future studies of HS.

Dataset Information

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Publications

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

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