Ontology highlight
ABSTRACT:
SUBMITTER: Han SJ
PROVIDER: S-EPMC7566738 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Han Sang Jun SJ Williams Ryan M RM Kim Mihwa M Heller Daniel A DA D'Agati Vivette V Schmidt-Supprian Marc M Lee H Thomas HT
JCI insight 20200917 19
We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle-encapsulated NEMO binding peptide (NBP MNP). We subjected renal PT NEMO-deficient mice, WT mice, and C57BL/6 mice to sham surgery or 30 minutes of renal ischemia and reperfusion (IR). C57BL/6 mice received NBP MNP or empty MNP before renal IR inju ...[more]