Ontology highlight
ABSTRACT:
SUBMITTER: Chu Y
PROVIDER: S-EPMC7566768 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chu Yeonjeong Y Raja Sekhara Reddy B B Pratap Reddy Gajulapalli V V Sudhakar Babu K K Kim Eunha E Lee Sanghee S
Bioorganic & medicinal chemistry letters 20201016 24
Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-molecule IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. In this study, we assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To inv ...[more]