Ontology highlight
ABSTRACT:
SUBMITTER: Fercher C
PROVIDER: S-EPMC7567157 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in molecular biosciences 20201002
TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent years, the structural organization and function of this intriguing molecule is still not clear. One outstanding difference between torsinA and other AAA+ ATPases is that torsinA is a glycoprotein. TorsinA <i>N</i>-linked glycans impact torsinA biogenesis and subcellular localization. Here, we propose that torsinA glycans also modulate torsi ...[more]