Knockdown THOC2 suppresses the proliferation and invasion of melanoma.
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ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC7567448 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Knockdown THOC2 suppresses the proliferation and invasion of melanoma.
Zhou Xiaowei X Liu Xing X Zhang Guoqiang G Zhang Qian Q Chen Hao H Wang Yan Y Fang Fang F Sun Jianfang J
Bioengineered 20191201 1
Melanoma is a potentially fatal form of skin cancer with great metastatic potential. THOC2 plays a vital role in human biological progression, however, the roles of THOC2 in melanoma tumorigenesis are still unknown. In the present study, our data demonstrated that THOC2 expression was significantly increased in melanoma tissues, and high THOC2 expression was associated with poor overall survival of melanoma patients. THOC2 reduction repressed melanoma cell proliferation and invasion, and induced ...[more]
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