A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC7567605 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body.
Wang Liping L Ding Yi Y He Li L Zhang Guiping G Zhu Jian-Kang JK Lozano-Duran Rosa R
eLife 20201016
In plants, establishment of de novo DNA methylation is regulated by the RNA-directed DNA methylation (RdDM) pathway. RdDM machinery is known to concentrate in the Cajal body, but the biological significance of this localization has remained elusive. Here, we show that the antiviral methylation of the <i>Tomato yellow leaf curl virus</i> (TYLCV) genome requires the Cajal body in <i>Nicotiana benthamiana</i> cells. Methylation of the viral genome is countered by a virus-encoded protein, V2, which ...[more]
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