On the existence and functionality of topologically associating domains.
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ABSTRACT:
SUBMITTER: Beagan JA
PROVIDER: S-EPMC7567612 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
On the existence and functionality of topologically associating domains.
Beagan Jonathan A JA Phillips-Cremins Jennifer E JE
Nature genetics 20200110 1
Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin domains. Topologically associating domains (TADs) were originally discovered empirically in low-resolution Hi-C heat maps representing ensemble average interaction frequencies from millions of cells. Here, we discuss recent advances in high-resolution Hi-C, single-cell imaging experiments, and functional genetic studies, which provide an increasingly complex view of the genome's hierarchical structure-function r ...[more]
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