Nephron Number and Time to Remission in Steroid-Sensitive Minimal Change Disease.

ABSTRACT:

Rationale & objective

The response to corticosteroid therapy may differ among patients with minimal change disease (MCD). Previous studies have suggested that glomerular hypertrophy or low areal glomerular density in biopsy specimens, which may be related to fewer nephrons, is associated with such a difference. We examined the associations between nephron number and the therapeutic response to corticosteroids in patients with MCD.

Study design

Retrospective cohort study.

Setting & participants

75 adult patients with a histologic diagnosis of MCD.

Exposure

Nephron number per kidney estimated based on the combination of unenhanced computed tomography and nonsclerotic volumetric glomerular density in kidney biopsy specimens.

Outcomes

Complete remission and

SUBMITTER: Sasaki T 

PROVIDER: S-EPMC7568083 | biostudies-literature | 2020 Sep-Oct

REPOSITORIES: biostudies-literature