Person-based similarity in brain structure and functional connectivity in bipolar disorder.

ABSTRACT:

Background

Bipolar disorder shows significant variability in clinical presentation. Here we adopt a personalized approach to quantify the brain structural and functional similarity of each individual patient to other patients and to healthy individuals.

Methods

Brain morphometric and resting-state functional connectivity measures from two independent samples of patients with bipolar disorder and healthy individuals (total number of participants=215) were modeled as single vectors to generated individualized morphometric and connectivity profiles. These profiles were then used to compute a person-based similarity indices which quantified the similarity in neuroimaging profiles amongst patients and between patients and health individuals.

Results

The morphometric and co

SUBMITTER: Doucet GE 

PROVIDER: S-EPMC7568424 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature