Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival.
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ABSTRACT:
SUBMITTER: Denner J
PROVIDER: S-EPMC7568528 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival.
Denner Joachim J Längin Matthias M Reichart Bruno B Krüger Luise L Fiebig Uwe U Mokelke Maren M Radan Julia J Mayr Tanja T Milusev Anastasia A Luther Fabian F Sorvillo Nicoletta N Rieben Robert R Brenner Paolo P Walz Christoph C Wolf Eckhard E Roshani Berit B Stahl-Hennig Christiane C Abicht Jan-Michael JM
Scientific reports 20201016 1
Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth of the transplant, prevention of transmission of the porcine cytomegalovirus (PCMV) plays an important role in achieving long survival times. For the first time we demonstrate that PCMV trans ...[more]
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