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Seven decades of chemotherapy clinical trials: a pan-cancer social network analysis.


ABSTRACT: Clinical trials establish the standard of cancer care, yet the evolution and characteristics of the social dynamics between the people conducting this work remain understudied. We performed a social network analysis of authors publishing chemotherapy-based prospective trials from 1946 to 2018 to understand how social influences, including the role of gender, have influenced the growth and development of this network, which has expanded exponentially from fewer than 50 authors in 1946 to 29,197 in 2018. While 99.4% of authors were directly or indirectly connected by 2018, our results indicate a tendency to predominantly connect with others in the same or similar fields, as well as an increasing disparity in author impact and number of connections. Scale-free effects were evident, with small numbers of individuals having disproportionate impact. Women were under-represented and likelier to have lower impact, shorter productive periods (P?

SUBMITTER: Li X 

PROVIDER: S-EPMC7568560 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Seven decades of chemotherapy clinical trials: a pan-cancer social network analysis.

Li Xuanyi X   Sigworth Elizabeth A EA   Wu Adrianne H AH   Behrens Jess J   Etemad Shervin A SA   Nagpal Seema S   Go Ronald S RS   Wuichet Kristin K   Chen Eddy J EJ   Rubinstein Samuel M SM   Venepalli Neeta K NK   Tillman Benjamin F BF   Cowan Andrew J AJ   Schoen Martin W MW   Malty Andrew A   Greer John P JP   Fernandes Hermina D HD   Seifter Ari A   Chen Qingxia Q   Chowdhery Rozina A RA   Mohan Sanjay R SR   Dewdney Summer B SB   Osterman Travis T   Ambinder Edward P EP   Buchbinder Elizabeth I EI   Schwartz Candice C   Abraham Ivy I   Rioth Matthew J MJ   Singh Naina N   Sharma Sanjai S   Gibson Michael K MK   Yang Peter C PC   Warner Jeremy L JL  

Scientific reports 20201016 1


Clinical trials establish the standard of cancer care, yet the evolution and characteristics of the social dynamics between the people conducting this work remain understudied. We performed a social network analysis of authors publishing chemotherapy-based prospective trials from 1946 to 2018 to understand how social influences, including the role of gender, have influenced the growth and development of this network, which has expanded exponentially from fewer than 50 authors in 1946 to 29,197 i  ...[more]

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