Kinase inhibition in autoimmunity and inflammation.
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ABSTRACT:
SUBMITTER: Zarrin AA
PROVIDER: S-EPMC7569567 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Kinase inhibition in autoimmunity and inflammation.
Zarrin Ali A AA Bao Katherine K Lupardus Patrick P Vucic Domagoj D
Nature reviews. Drug discovery 20201019 1
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet medical needs in some areas still exist. One of the main therapeutic approaches to alleviate dysregulated inflammation has been to target the activity of kinases that regulate production of inflammatory mediators. Small-molecule kinase inhibitors have the potential for broad efficacy, convenience and tissue penetrance, and thus often offer important advantages over biologics. However, designing kinase inhibit ...[more]
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