Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC7569743 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Xiao X King-Smith Emma E Dong Liao-Bin LB Yang Li-Cheng LC Rudolf Jeffrey D JD Shen Ben B Renata Hans H
Science (New York, N.Y.) 20200801 6505
Polycyclic diterpenes exhibit many important biological activities, but de novo synthetic access to these molecules is highly challenging because of their structural complexity. Semisynthetic access has also been limited by the lack of chemical tools for scaffold modifications. We report a chemoenzymatic platform to access highly oxidized diterpenes by a hybrid oxidative approach that strategically combines chemical and enzymatic oxidation methods. This approach allows for selective oxidations o ...[more]