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Three New Oleanane-Type Triterpenoidal Glycosides from Impatiens balsamina and Their Biological Activity.

ABSTRACT: Three new oleanane-type triterpenoidal glycosides, imbalosides A-C (1-3), were isolated from the white flowers of Impatiens balsamina. The structures of these phytochemical constituents (1-3) were elucidated through 1D and 2D Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) data analyses followed by chemical methods. All the characterized compounds (1-3) were evaluated for their antiproliferative activity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and BT549) and their anti-neuroinflammatory activity on the basis of inhibition levels of nitric oxide (NO) in the lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell lines.

SUBMITTER: Lee TH

PROVIDER: S-EPMC7570163 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Three New Oleanane-Type Triterpenoidal Glycosides from Impatiens balsamina and Their Biological Activity.

Lee Tae Hyun TH Suh Won Se WS Subedi Lalita L Kim Sun Yeou SY Choi Sang Un SU Lee Kang Ro KR Kim Chung Sub CS

Plants (Basel, Switzerland) 20200824 9

Three new oleanane-type triterpenoidal glycosides, imbalosides A-C (1-3), were isolated from the white flowers of Impatiens balsamina. The structures of these phytochemical constituents (1-3) were elucidated through 1D and 2D Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) data analyses followed by chemical methods. All the characterized compounds (1-3) were evaluated for their antiproliferative activity against four human tumor cell l ...[more]

PMID: 32846890

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