Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Juarbe N
PROVIDER: S-EPMC7570217 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gonzalez-Juarbe Norberto N Riegler Ashleigh N AN Jureka Alexander S AS Gilley Ryan P RP Brand Jeffrey D JD Trombley John E JE Scott Ninecia R NR Platt Maryann P MP Dube Peter H PH Petit Chad M CM Harrod Kevin S KS Orihuela Carlos J CJ
Cell reports 20200801 8
Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the impact of IAV on PFT-induced acute lung injury during co- and secondary Streptococcus pneumoniae (Spn) infection. We observe that IAV synergistically sensitizes lung epithelial cell ...[more]