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Dynamic Expression Profiles of ?-Catenin during Murine Cardiac Valve Development.


ABSTRACT: ?-catenin has been widely studied in many animal and organ systems across evolution, and gain or loss of function has been linked to a number of human diseases. Yet fundamental knowledge regarding its protein expression and localization remains poorly described. Thus, we sought to define whether there was a temporal and cell-specific regulation of ?-catenin activities that correlate with distinct cardiac morphological events. Our findings indicate that activated nuclear ?-catenin is primarily evident early in gestation. As development proceeds, nuclear ?-catenin is down-regulated and becomes restricted to the membrane in a subset of cardiac progenitor cells. After birth, little ?-catenin is detected in the heart. The co-expression of ?-catenin with its main transcriptional co-factor, Lef1, revealed that Lef1 and ?-catenin expression domains do not extensively overlap in the cardiac valves. These data indicate mutually exclusive roles for Lef1 and ?-catenin in most cardiac cell types during development. Additionally, these data indicate diverse functions for ?-catenin within the nucleus and membrane depending on cell type and gestational timing. Cardiovascular studies should take into careful consideration both nuclear and membrane ?-catenin functions and their potential contributions to cardiac development and disease.

SUBMITTER: Guo L 

PROVIDER: S-EPMC7570242 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Dynamic Expression Profiles of β-Catenin during Murine Cardiac Valve Development.

Guo Lilong L   Glover Janiece J   Risner Alyssa A   Wang Christina C   Fulmer Diana D   Moore Kelsey K   Gensemer Cortney C   Rumph Mary Kate MK   Moore Reece R   Beck Tyler T   Norris Russell A RA  

Journal of cardiovascular development and disease 20200817 3


β-catenin has been widely studied in many animal and organ systems across evolution, and gain or loss of function has been linked to a number of human diseases. Yet fundamental knowledge regarding its protein expression and localization remains poorly described. Thus, we sought to define whether there was a temporal and cell-specific regulation of β-catenin activities that correlate with distinct cardiac morphological events. Our findings indicate that activated nuclear β-catenin is primarily ev  ...[more]

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