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First Class of Phosphorus Dendritic Compounds Containing ?-Cyclodextrin Units in the Periphery Prepared by CuAAC.

ABSTRACT: A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (P3N3) core and decorated with six ?-cyclodextrin (?CD) units, named P3N3-[O-C6H4-O-(CH2)n-?CD]6, where n = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the P3N3, two linkers consisting of an aromatic ring and an aliphatic chain of two different lengths were assessed. We found that, with both linkers, the total modification of the periphery was achieved. The two new obtained dendritic compounds presented a considerably high water solubility (>1 g/mL). The compounds comprised in this new class of PDCs are potential drug carrier candidates, since the conjugation of the ?CD units to the P3N3 core through the primary face will not only serve as surface cover but, also, provide them the faculty to encapsulate various drugs inside the ?CDs cavities.

SUBMITTER: Sorroza-Martinez K 

PROVIDER: S-EPMC7570757 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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First Class of Phosphorus Dendritic Compounds Containing β-Cyclodextrin Units in the Periphery Prepared by CuAAC.

Sorroza-Martínez Kendra K   González-Méndez Israel I   Vonlanthen Mireille M   Moineau-Chane Ching Kathleen I KI   Caminade Anne-Marie AM   Illescas Javier J   Rivera Ernesto E  

Molecules (Basel, Switzerland) 20200904 18

A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (P<sub>3</sub>N<sub>3</sub>) core and decorated with six β-cyclodextrin (βCD) units, named P<sub>3</sub>N<sub>3</sub>-[O-C<sub>6</sub>H<sub>4</sub>-O-(CH<sub>2</sub>)<sub>n</sub>-βCD]<sub>6</sub>, where <i>n</i> = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the P<sub>3</sub>N<sub>3</sub>, two linkers consi  ...[more]

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