Ontology highlight
ABSTRACT:
SUBMITTER: Carofiglio F
PROVIDER: S-EPMC7570842 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Carofiglio Francesca F Trisciuzzi Daniela D Gambacorta Nicola N Leonetti Francesco F Stefanachi Angela A Nicolotti Orazio O
Molecules (Basel, Switzerland) 20200914 18
The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition regulatory module observed in the progenitor kinase c-Abl is lost in the aberrant Bcr-Abl, because of the lack of the <i>N</i>-myristoylated cap able to bind the myristoyl binding pocket also conserved in the Bcr-Abl kinase domain. A way to overcome the occurrence of resistance phenomena frequently observed for Bcr-Abl orthosteric drugs is t ...[more]