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Antimicrobial Activity of Gemini Surfactants with Azapolymethylene Spacer.

ABSTRACT: A series of 21 azapolymethylene gemini surfactants were obtained. The synthesis of the title surfactants in one- or two-step reaction proceeds with good yields. The structure and the purity of the synthesized compounds were determined by 1H and 13C NMR, ESI-MS spectra, and elemental analysis. Moreover, 2D COSY, HMBC, and HSQC spectra were performed. The minimal inhibitory concentrations (MIC) of the synthesized compounds were determined against fungi: Candida albicans, Aspergillus niger, Penicillium chrysogenum and bacteria: Escherichia coli,Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. Also, the critical micelle concentrations (CMC) were determined. The relationship between antimicrobial and surface activity and surfactant structure has been determined.

SUBMITTER: Kowalczyk I 

PROVIDER: S-EPMC7571221 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Antimicrobial Activity of Gemini Surfactants with Azapolymethylene Spacer.

Kowalczyk Iwona I   Pakiet Marta M   Szulc Adrianna A   Koziróg Anna A  

Molecules (Basel, Switzerland) 20200904 18

A series of 21 azapolymethylene gemini surfactants were obtained. The synthesis of the title surfactants in one- or two-step reaction proceeds with good yields. The structure and the purity of the synthesized compounds were determined by <sup>1</sup>H and <sup>13</sup>C NMR, ESI-MS spectra, and elemental analysis. Moreover, 2D COSY, HMBC, and HSQC spectra were performed. The minimal inhibitory concentrations (MIC) of the synthesized compounds were determined against fungi: <i>Candida albicans, A  ...[more]

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