Prognosis Analysis and Validation of m⁶A Signature and Tumor Immune Microenvironment in Glioma.

ABSTRACT: Glioma is one of the most typical intracranial tumors, comprising about 80% of all brain malignancies. Several key molecular signatures have emerged as prognostic biomarkers, which indicate room for improvement in the current approach to glioma classification. In order to construct a more veracious prediction model and identify the potential prognosis-biomarker, we explore the differential expressed m⁶A RNA methylation regulators in 665 gliomas from TCGA-GBM and TCGA-LGG. Consensus clustering was applied to the m6A RNA methylation regulators, and two glioma subgroups were identified with a poorer prognosis and a higher grade of WHO classification in cluster 1. The further chi-squared test indicated that the immune infiltration was significantly enriched in cluster 1, indicating

SUBMITTER: Lin S 

PROVIDER: S-EPMC7571468 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature