Ontology highlight
ABSTRACT:
SUBMITTER: Guler GD
PROVIDER: S-EPMC7572413 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nature communications 20201019 1
Pancreatic cancer is often detected late, when curative therapies are no longer possible. Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5-hydroxymethylcytosine (5hmC) changes in circulating cell free DNA from a PDAC cohort (n = 64) in comparison with a non-cancer cohort (n = 243). Differential hydroxymethylation is found in thousands of genes, most significantly in genes related to pancreas development or function (GATA4, GATA6, PROX1, ONECUT1, MEIS2), and ...[more]