The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer.
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ABSTRACT:
SUBMITTER: Cheng S
PROVIDER: S-EPMC7572469 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer.
Cheng Siyuan S Prieto-Dominguez Nestor N Yang Shu S Connelly Zachary M ZM StPierre Samantha S Rushing Bryce B Watkins Andy A Shi Lawrence L Lakey Meredith M Baiamonte Lyndsey Buckner LB Fazili Tajammul T Lurie Aubrey A Corey Eva E Shi Runhua R Yeh Yunshin Y Yu Xiuping X
Prostate cancer and prostatic diseases 20200420 4
<h4>Background</h4>After long-term androgen deprivation therapy, 25-30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has been related to cancer progression. However, its role in neuroendocrine prostate cancer (NEPC) has not been assessed.<h4>Methods</h4>Immunohistochemistry and bioinformatics analysis were conducted to evaluate YAP1 expression levels during PCa initiation and progression.< ...[more]
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