A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
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ABSTRACT:
SUBMITTER: Hsiao K
PROVIDER: S-EPMC7572771 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Working memory is a form of short-term memory that involves maintaining and updating task relevant information toward goal-directed pursuits. Classical models posit persistent activity in prefrontal cortex (PFC) as a primary neural correlate, but emerging views suggest additional mechanisms may exist. We screened ~200 genetically diverse mice on a working memory task and identified a genetic locus on Chromosome 5 that contributes to a substantial proportion (17%) of the phenotypic variance. Within the locus, we identified a gene encoding an orphan G-protein coupled receptor, Gpr12, which is sufficient to drive substantial and bi-directional changes in working memory. Molecular, cellular, and imaging studies revealed that Gpr12 enables high thalamus-PFC synchrony to support memory maintenance and choice accuracy. These findings identify a novel orphan receptor as a potent modifier of short-term memory, and supplement classical PFC-based models with an emerging thalamus-centric framework for the mechanistic understanding of working memory.
2020-10-01 | GSE156836 | GEO
Project description:A Thalamic Orphan Receptor Drives Variability in Short Term Memory
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