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From BDNF to reading: Neural activation and phonological processing as multiple mediators.

ABSTRACT: The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val⁶⁶Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading-related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5-13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with brain activation in reading-related and more domain general regions which in turn is associated with phonological processing which is associated with reading. These findings suggest that the BDNF-Val⁶⁶Met polymorphism is related to reading via phonological processing and functional activation. These results support brain imaging data and neurocognitive traits as viable IPs for complex behaviors.

SUBMITTER: Mascheretti S

PROVIDER: S-EPMC7572787 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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From BDNF to reading: Neural activation and phonological processing as multiple mediators.

Mascheretti Sara S Perdue Meaghan V MV Feng Bei B Andreola Chiara C Dionne Ginette G Jasińska Kaja K KK Pugh Kenneth R KR Grigorenko Elena L EL Landi Nicole N

Behavioural brain research 20200815

The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val<sup>66</sup>Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading-related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain ac ...[more]

PMID: 32810467

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Project description:Behavioral research shows that children's phonological ability is strongly associated with better word reading skills, whereas semantic knowledge is strongly related to better reading comprehension. However, most neuroscience research has investigated how brain activation during phonological and semantic processing is related to word reading skill. This study examines if connectivity during phonological processing in the dorsal inferior frontal gyrus (dIFG) to posterior superior temporal gyrus (pSTG) pathway is related to word reading skill, whereas connectivity during semantic processing in the ventral inferior frontal gyrus (vIFG) to posterior middle temporal gyrus (pMTG) pathway is related to reading comprehension skill. We used behavioral and functional magnetic resonance imaging (fMRI) data from a publicly accessible dataset on OpenNeuro.org. The research hypotheses and analytical plan were pre-registered on the Open Science Framework. Forty-six children ages 8-15 years old were included in the final analyses. Participants completed an in-scanner reading task tapping into phonology (i.e., word rhyming) and semantics (i.e., word meaning) as well as standardized measures of word reading and reading comprehension skill. In a series of registered and exploratory analyses, we correlated connectivity coefficients from generalized psychophysiological interactions (gPPI) with behavioral measures and used z-scores to test the equality of two correlation coefficients. Results from the preregistered and exploratory analyses indicated weak evidence that functional connectivity of dIFG to pSTG during phonological processing is positively correlated with better word reading skill, but no evidence that connectivity in the vIFG-pMTG pathway during semantic processing is related to better reading comprehension skill. Moreover, there was no evidence to support the differentiation between the dorsal pathway's relation to word reading and the ventral pathway's relation to reading comprehension skills. Our finding suggesting the importance of phonological processing to word reading is in line with prior behavioral and neurodevelopmental models.

Dataset Information

From BDNF to reading: Neural activation and phonological processing as multiple mediators.

Publications

From BDNF to reading: Neural activation and phonological processing as multiple mediators.

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