Ontology highlight
ABSTRACT:
SUBMITTER: Lee JE
PROVIDER: S-EPMC7572814 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lee Ji-Eun JE Cho Sung-Gook SG Ko Seong-Gyu SG Ahrmad Syed A SA Puga Alvaro A Kim Kyounghyun K
Biochemical and biophysical research communications 20200906 4
Environmental toxicants such as dioxins and polycyclic aromatic carbons are risk factors for pancreatitis and pancreatic cancer. These toxicants activate aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, of which activation regulates many downstream biological events, including xenobiotic metabolism, inflammation, and cancer cell growth and transformation. Here, we identified that environmental toxicant-activated AHR increased expression of metastasis associated lung aden ...[more]