Ontology highlight
ABSTRACT:
SUBMITTER: Masuho I
PROVIDER: S-EPMC7572916 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Masuho Ikuo I Balaji Santhanam S Muntean Brian S BS Skamangas Nickolas K NK Chavali Sreenivas S Tesmer John J G JJG Babu M Madan MM Martemyanov Kirill A KA
Cell 20201001 2
The control over the extent and timing of G protein signaling is provided by the regulator of G protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian genomes encode 20 canonical RGS and 16 Gα genes with key roles in physiology and disease. To understand the principles governing the selectivity of Gα regulation by RGS, we examine the catalytic activity of all canonical human RGS proteins and their selectivity for a complete set of Gα substrates using real-time kine ...[more]