Ontology highlight
ABSTRACT:
SUBMITTER: Lodde V
PROVIDER: S-EPMC7573158 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lodde Valeria V Floris Matteo M Beerman Isabel I Munk Rachel R Guha Rajan R Steri Maristella M Orrù Valeria V Abdelmohsen Kotb K Crompton Peter D PD Gorospe Myriam M Idda Maria Laura ML Cucca Francesco F
Frontiers in immunology 20201006
We have previously shown that a variant of the <i>TNFSF13B</i> gene that we called <i>BAFF-var</i> increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population signatures revealed that <i>BAFF-var</i> was evolutionarily advantageous, most likely by increasing resistance to malaria infection, which is a prime candidate for selective pressure. To evaluate whether the increased soluble BAFF (sBA ...[more]