Immunomodulatory Drugs in Acute Myeloid Leukemia Treatment.
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ABSTRACT:
SUBMITTER: Piccolomo A
PROVIDER: S-EPMC7573974 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Immunomodulatory Drugs in Acute Myeloid Leukemia Treatment.
Piccolomo Antonio A Schifone Claudia Pia CP Strafella Vanda V Specchia Giorgina G Musto Pellegrino P Albano Francesco F
Cancers 20200905 9
Immunomodulatory drugs (IMiDs) are analogs of thalidomide. They have immunomodulatory, antiangiogenic and proapoptotic properties and exert a role in regulating the tumor microenvironment. Recently IMiDs have been investigated for their pleiotropic properties and their therapeutic applications in both solid tumors (melanoma, prostate carcinoma and differentiated thyroid cancer) and hematological malignancies. Nowadays, they are applied in de novo and relapsed/refractory multiple myeloma, in myel ...[more]
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