Ontology highlight
ABSTRACT:
SUBMITTER: Townsend LB
PROVIDER: S-EPMC7574469 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Townsend Leah B LB Jones Kelly A KA Dorsett Christopher R CR Philpot Benjamin D BD Smith Spencer L SL
Journal of neurodevelopmental disorders 20201019 1
<h4>Background</h4>Sensory processing deficits are common in individuals with neurodevelopmental disorders. One hypothesis is that deficits may be more detectable in downstream, "higher" sensory areas. A mouse model of Angelman syndrome (AS), which lacks expression of the maternally inherited Ube3a allele, has deficits in synaptic function and experience-dependent plasticity in the primary visual cortex. Thus, we hypothesized that AS model mice have deficits in visually driven neuronal responsiv ...[more]