The contribution of non-coding regulatory elements to cardiovascular disease.
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ABSTRACT:
SUBMITTER: Villar D
PROVIDER: S-EPMC7574544 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
The contribution of non-coding regulatory elements to cardiovascular disease.
Villar Diego D Frost Stephanie S Deloukas Panos P Tinker Andrew A
Open biology 20200701 7
Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate loci. Here, we review genetic, epigenomic and molecular approaches to investigate the contribution of non-coding regulatory elements in cardiovascular biology. We then discuss recent insights on the emerging role of non-coding variation in predi ...[more]
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