Ontology highlight
ABSTRACT:
SUBMITTER: Chan KK
PROVIDER: S-EPMC7574912 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chan Kui K KK Dorosky Danielle D Sharma Preeti P Abbasi Shawn A SA Dye John M JM Kranz David M DM Herbert Andrew S AS Procko Erik E
Science (New York, N.Y.) 20200804 6508
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at buried sites. The mutational landscape provides a blueprint for understanding the sp ...[more]