Ontology highlight
ABSTRACT:
SUBMITTER: Gjerga E
PROVIDER: S-EPMC7575044 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gjerga Enio E Trairatphisan Panuwat P Gabor Attila A Koch Hermann H Chevalier Celine C Ceccarelli Franceco F Dugourd Aurelien A Mitsos Alexander A Saez-Rodriguez Julio J
Bioinformatics (Oxford, England) 20200801 16
<h4>Summary</h4>The molecular changes induced by perturbations such as drugs and ligands are highly informative of the intracellular wiring. Our capacity to generate large datasets is increasing steadily. A useful way to extract mechanistic insight from the data is by integrating them with a prior knowledge network of signalling to obtain dynamic models. CellNOpt is a collection of Bioconductor R packages for building logic models from perturbation data and prior knowledge of signalling networks ...[more]