Dataset Information

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders.

ABSTRACT: Neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) suffer from the lack of risk-predictive circulating biomarkers, and clinical diagnosis occurs only when symptoms are evident. Among potential biomarkers, platelet parameters have been associated with both disorders. However, these associations have been scarcely investigated at the genetic level. Here, we tested genome-wide coheritability based on common genetic variants between platelet parameters and PD/AD risk, through Linkage Disequilibrium Score Regression. This revealed a significant genetic correlation between platelet distribution width (PDW), an index of platelet size variability, and PD risk (rg [SE] = 0.080 [0.034]; p = 0.019), which was confirmed by a summary-summary polygenic score analysis, where PDW explained a small but significant proportion PD risk (<1%). AD risk showed no significant correlations, although a negative trend was observed with PDW (rg [SE] =-0.088 [0.053]; p=0.096), in line with previous epidemiological reports. These findings suggest the existence of limited shared genetic bases between PDW and PD and warrant further investigations to clarify the genes involved in this relation. Additionally, they suggest that the association between platelet parameters and AD risk is more environmental in nature, prompting an investigation into which factors may influence these traits.

SUBMITTER: Tirozzi A

PROVIDER: S-EPMC7575686 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders.

Tirozzi Alfonsina A Izzi Benedetta B Noro Fabrizia F Marotta Annalisa A Gianfagna Francesco F Hoylaerts Marc F MF Cerletti Chiara C Donati Maria Benedetta MB de Gaetano Giovanni G Iacoviello Licia L Gialluisi Alessandro A

Frontiers in immunology 20201007

Neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) suffer from the lack of risk-predictive circulating biomarkers, and clinical diagnosis occurs only when symptoms are evident. Among potential biomarkers, platelet parameters have been associated with both disorders. However, these associations have been scarcely investigated at the genetic level. Here, we tested genome-wide coheritability based on common genetic variants between platelet parameters and PD/A ...[more]

PMID: 33117333

Similar Datasets

Project description:Food reward is an important concept for research in eating behaviors. Many food reward tasks have been developed and are in active use. However, little is known how much these tasks overlap. Here, we sought to compare three promising food reward tasks: (1) the Leeds Food Preference Questionnaire (LFPQ; a procedure combining explicit ratings of wanting and liking and an implicit wanting task based on forced choice), (2) a hand grip force task, and (3) an emotional attentional blink (EAB) task. Specifically, we assessed whether the tasks are sensitive to changes in hunger, correlate with each other, and correlate with trait binge eating and snack food calorie intake. Thirty-nine women aged 25.51 ± 5.99 years, with a BMI of 22.51 ± 3.58 kg/m2 completed the three tasks twice: after a 6-h fast and following a breakfast meal. In the fasted condition, participants were also given ad libitum access to snack foods to assess calorie intake. Prior to the two laboratory sessions, participants completed a trait binge eating questionnaire. Results revealed that the LFPQ's explicit wanting and explicit liking subscales, as well as grip force reflected higher food reward scores in the fasted condition. The three metrics also correlated positively with each other. Explicit wanting and liking correlated with snack food intake, while grip force did not. None of the tasks were related to trait binge eating. Reaction times in the forced choice procedure did not reflect changes in hunger, but the task was nevertheless able to differentiate between foods varying in taste and fat content. The EAB was not sensitive to the hunger manipulation; neither did the task correlate with binge eating or energy intake. Collectively, our findings suggest that the explicit wanting and liking scales and the grip force task measure the same construct, whereas EAB results may be obscured by a variety of potential confounding factors. Future research could include additional food reward tasks in comparisons, measure covariates that may moderate the variables' associations, and compare hunger-dependent changes in food reward in different subgroups.

Dataset Information

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders.

Publications

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets