Ontology highlight
ABSTRACT:
SUBMITTER: Jamshidi N
PROVIDER: S-EPMC7575880 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Jamshidi Neema N Xu Xiuling X von Löhneysen Katharina K Soldau Katrin K Mohney Rob P RP Karoly Edward D ED Scott Mike M Friedman Jeffrey S JS
iScience 20200929 10
Understanding the mechanisms for cellular aging is a fundamental question in biology. Normal red blood cells (RBCs) survive for approximately 100 days, and their survival is likely limited by functional decline secondary to cumulative damage to cell constituents, which may be reflected in altered metabolic capabilities. To investigate metabolic changes during <i>in vivo</i> RBC aging, labeled cell populations were purified at intervals and assessed for abundance of metabolic intermediates using ...[more]