Ontology highlight
ABSTRACT:
SUBMITTER: Calizo RC
PROVIDER: S-EPMC7576209 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Calizo R C RC Bell M K MK Ron A A Hu M M Bhattacharya S S Wong N J NJ Janssen W G M WGM Perumal G G Pederson P P Scarlata S S Hone J J Azeloglu E U EU Rangamani P P Iyengar R R
Scientific reports 20201020 1
The shape of the cell is connected to its function; however, we do not fully understand underlying mechanisms by which global shape regulates a cell's functional capabilities. Using theory, experiments and simulation, we investigated how physiologically relevant cell shape changes affect subcellular organization, and consequently intracellular signaling, to control information flow needed for phenotypic function. Vascular smooth muscle cells going from a proliferative and motile circular shape t ...[more]