Drug discovery and treatment paradigms in nonalcoholic steatohepatitis.
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ABSTRACT:
SUBMITTER: Noureddin M
PROVIDER: S-EPMC7576222 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Drug discovery and treatment paradigms in nonalcoholic steatohepatitis.
Noureddin Mazen M Muthiah Mark D MD Sanyal Arun J AJ
Endocrinology, diabetes & metabolism 20191210 4
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western populations, and is closely associated with features of the metabolic syndrome. The burden of disease is set to rise exponentially, and this is further compounded by the lack of good medications. In addition, these patients tend to have multiple comorbidities that may not be adequately managed. In this article, we review the biological basis of potential therapies in nonalcoholic steatohepatitis (NASH), ...[more]
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Project description:BackgroundThe increasing prevalence of nonalcoholic -fatty liver disease has led to a strong demand for an optimal therapeutic approach. At present, guidelines recommend lifestyle changes, but it has become apparent that pharmacotherapy will be required in patients with advanced disease to prevent the progression to end-stage liver disease and potentially improve extrahepatic outcomes.SummaryThis review discusses current pharmacological approaches focusing on substances studied in pivotal trials and selected phase 2 trials in patients with nonalcoholic steatohepatitis (NASH) and fibrosis.Key messageCurrently, several compounds are subjected to clinical testing to explore predominantly anti-inflammatory, anti-fibrotic, and metabolic treatment for NASH. With current response rates around 20%, the combination of several drugs targeting more than one pathway could lead to increased treatment success in the future.
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