Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7576259 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Zuyun Z Leung Diana D Thrush Kyra K Zhao Wei W Ratliff Scott S Tanaka Toshiko T Schmitz Lauren L LL Smith Jennifer A JA Ferrucci Luigi L Levine Morgan E ME
Aging cell 20200915 10
Epigenetic clocks, developed using DNA methylation data, have been widely used to quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks are weakly correlated with each other, suggesting they may capture different biological processes. We utilize multi-omics data from diverse human tissue/cells to identify shared features across eleven existing epigenetic clocks. Despite the striking lack of overlap in CpGs, multi-omics analysis suggested five clocks (Horva ...[more]