Ontology highlight
ABSTRACT:
SUBMITTER: Del Llano E
PROVIDER: S-EPMC7576272 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Del Llano Edgar E Masek Tomas T Gahurova Lenka L Pospisek Martin M Koncicka Marketa M Jindrova Anna A Jansova Denisa D Iyyappan Rajan R Roucova Kristina K Bruce Alexander W AW Kubelka Michal M Susor Andrej A
Aging cell 20200920 10
Increasing maternal age in mammals is associated with poorer oocyte quality, involving higher aneuploidy rates and decreased developmental competence. Prior to resumption of meiosis, fully developed mammalian oocytes become transcriptionally silent until the onset of zygotic genome activation. Therefore, meiotic progression and early embryogenesis are driven largely by translational utilization of previously synthesized mRNAs. We report that genome-wide translatome profiling reveals considerable ...[more]