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Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases.


ABSTRACT: Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols' bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin-hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin-hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

SUBMITTER: Menezes R 

PROVIDER: S-EPMC7576474 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases.

Menezes Regina R   Foito Alexandre A   Jardim Carolina C   Costa Inês I   Garcia Gonçalo G   Rosado-Ramos Rita R   Freitag Sabine S   Alexander Colin James CJ   Outeiro Tiago Fleming TF   Stewart Derek D   Santos Cláudia N CN  

Antioxidants (Basel, Switzerland) 20200826 9


Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized <i>Rubus</i> species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols' bioactivity using a yeast-based discovery pla  ...[more]

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