Ontology highlight
ABSTRACT:
SUBMITTER: Marsot A
PROVIDER: S-EPMC7576626 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Marsot Amélie A Ménard Amélie A Dupouey Julien J Allanioux Laurent L Blin Olivier O Guilhaumou Romain R
British journal of clinical pharmacology 20200513 11
For management of osteoarticular infections, rifampicin appears to be the key antibiotic. We aimed to evaluate the actual rifampicin dosing regimens using a population pharmacokinetic model of rifampicin in patients with osteoarticular infections. A Monte Carlo simulation study was performed to simulate steady-state plasma concentrations for 1000 randomly sampled subjects using a total daily dose between 600 and 1200 mg (600 and 900 mg once daily, 450 and 600 mg twice daily, or 300 mg 3 times da ...[more]