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Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry.

ABSTRACT: Alcohol abuse is a chronic disease characterized by the consumption of alcohol at a level that interferes with physical and mental health and causes serious and persistent changes in the brain. Lipid metabolism is of particular interest due to its high concentration in the brain. Lipids are the main component of cell membranes, are involved in cell signaling, signal transduction, and energy storage. In this study, we analyzed lipid composition of chronically ethanol exposed mouse brains. Juvenile (JUV) and adult (ADU) mice were placed on a daily limited-access ethanol intake model for 52 days. After euthanasia, brains were harvested, and total lipids were extracted from brain homogenates. Samples were analyzed using high resolution mass spectrometry and processed by multivariate and univariate statistical analysis. Significant lipid changes were observed in different classes including sphingolipids, fatty acids, lysophosphatidylcholines, and other glycerophospholipids.

SUBMITTER: Roux A 

PROVIDER: S-EPMC7577215 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry.

Roux Aurelie A   Jackson Shelley N SN   Muller Ludovic L   Barbacci Damon D   O'Rourke Joseph J   Thanos Panayotis K PK   Volkow Nora D ND   Balaban Carey C   Schultz J Albert JA   Woods Amina S AS  

ACS chemical neuroscience 20160620 8

Alcohol abuse is a chronic disease characterized by the consumption of alcohol at a level that interferes with physical and mental health and causes serious and persistent changes in the brain. Lipid metabolism is of particular interest due to its high concentration in the brain. Lipids are the main component of cell membranes, are involved in cell signaling, signal transduction, and energy storage. In this study, we analyzed lipid composition of chronically ethanol exposed mouse brains. Juvenil  ...[more]

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