The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor.
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ABSTRACT:
SUBMITTER: Kaur J
PROVIDER: S-EPMC7577423 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor.
Kaur Jatinder J Bhardwaj Atul A Melancon Bruce J BJ Blagg Brian S J BSJ
Synthetic communications 20190423 11
AT13387 is an orally bioavailable clinical candidate developed to inhibit theheat shock protein 90 (Hsp90). This article describes a modified synthetic route for the multi-gram production of AT13387 in 46% overall yield. The modified synthetic route is short, avoids stringent reaction conditions and difficult purifications, which led to increase in an overall yield. ...[more]
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