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ABSTRACT:
SUBMITTER: Mukherjee A
PROVIDER: S-EPMC7577492 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Mukherjee Abhishek A Barai Amlan A Singh Ramesh K RK Singh Ramesh K RK Yan Wenyi W Sen Shamik S
PLoS computational biology 20201009 10
Large nuclear deformations during migration through confined spaces have been associated with nuclear membrane rupture and DNA damage. However, the stresses associated with nuclear damage remain unclear. Here, using a quasi-static plane strain finite element model, we map evolution of nuclear shape and stresses during confined migration of a cell through a deformable matrix. Plastic deformation of the nucleus observed for a cell with stiff nucleus transiting through a stiffer matrix lowered nucl ...[more]