Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC7577810 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Park Sehhoon S Ku Bo Mi BM Jung Hyun Ae HA Sun Jong-Mu JM Ahn Jin Seok JS Lee Se-Hoon SH Park Keunchil K Ahn Myung-Ju MJ
Cancer research and treatment 20200622 4
The non-small cell lung cancer with activating epidermal growth factor receptor (EGFR) mutation eventually acquires resistant to either first or second-generation EGFR tyrosine kinase inhibitor (TKI). As the following option, targeting EGFR T790M with third-generation EGFR TKI is now established as a standard treatment option. In this study, we are reporting the first case of resistance mechanism to the novel third-generation EGFR TKI, lazertinib, which showed promising clinical efficacy in phas ...[more]