Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods.
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ABSTRACT:
SUBMITTER: Ball K
PROVIDER: S-EPMC7577828 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods.
Ball Kristen K Kinne Renee R Aguirre Aitor A
Journal of visualized experiments : JoVE 20200310 157
Congenital heart defects (CHD) are the most common type of birth defect in humans, affecting up to 1% of all live births. However, the underlying causes for CHD are still poorly understood. The developing mouse constitutes a valuable model for the study of CHD, because cardiac developmental programs between mice and humans are highly conserved. The protocol describes in detail how to produce mouse embryos of the desired gestational stage, methods to isolate and preserve the heart for downstream ...[more]
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