Ontology highlight
ABSTRACT:
SUBMITTER: Yu Q
PROVIDER: S-EPMC7577858 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Yu Qianhui Q He Zhisong Z Zubkov Dmitry D Huang Shuyun S Kurochkin Ilia I Yang Xiaode X Halene Tobias T Willmitzer Lothar L Giavalisco Patrick P Akbarian Schahram S Khaitovich Philipp P
Molecular psychiatry 20180808 11
Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down syndrome (DS). Of the 5024 detected lipids, 95% showed significant age-dependent concentration differences clustering into four temporal stages, and resulting in a gradual increase in m ...[more]