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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.

ABSTRACT: The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

SUBMITTER: Wrobel AG 

PROVIDER: S-EPMC7577971 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.

Wrobel Antoni G AG   Benton Donald J DJ   Hussain Saira S   Harvey Ruth R   Martin Stephen R SR   Roustan Chloë C   Rosenthal Peter B PB   Skehel John J JJ   Gamblin Steven J SJ  

Nature communications 20201021 1

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike. ...[more]

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